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Olanzapine is used for short-term treatment of agitation caused by schizophrenia or bipolar disorder.



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Zyprexa generic equivalent (eg, valproate) and at least one metabolite (eg, dexamethasone valerate) were measured. Study methods Study participants gave informed consent. They underwent a screening questionnaire to assess their mental health status, which was supplemented by a series of questionnaires. The study was approved by institutional review boards at the University of Pennsylvania and Bristol. A history of psychiatric symptoms and a family history of schizophrenia, bipolar disorder, and drug abuse were recorded before the study and during study. All measures were collected between February 2000 and May 2002, results were collected from May 2003 through June 2006. The following screening tools were used for diagnoses (Table 1): the Psychotic Experiences Scale (PES), Family History of Schizophrenia and Bipolar Disorder (FHbpd1) questionnaire, the Structured Clinical Interview for DSM–III–R Axis I Disorders.14 Although participants completed the PES, FFHbpd1 was administered by trained research staff and is not a comprehensive diagnostic screen. Table 1. First-episode psychosis* schizophrenia** P PDSS score (0–9) P* SCID-I (0–40) SCID-II score Comorbid psychosis† Yes§ No* Alcohol (units/wk)b 2.9 (2.5) 1.9 (1.8) 2.2 (2.0) 3.7 (3.9) (2.1) <0.0001 Gender (female)c 9.7 (13.4) 8.0 (5.6) 8.3 8.2 (4.9) 7.8 <0.0001 Current smokerd 9.3 (20.7) 8.8 (6.0) Zyprex 4mg $84.27 - $1.4 Per pill 7.7 (4.9) 7.2 (5.2) 6.3 (3.6) 0.003 Education (years)e 0.2 (.7) 1.0 (1.4) 1.5 (1.6) 1.11 0.93 (1.2) 0.0001 Race/ethnicity (non-Hispanic whites)c 4.4 (4.7) 6.4 (4.6) 0.9 (0.8) 0.3 (0.2) 0.2 0.003 Age at onset (years)c 10.2 (14.0) 7.8 (5.7) 4.4 (3.9) 4.8 (3.3) (3.4) 0.03 Current use (cigarettes/d)e 1.1 (0.6) 0.5 (0.4) 0.8 (0.7) 1.0 (0.6) 0.6 (0.5) 0.0017 DSM-IV psychotic symptoms** No psychosis† 1.5 (2.7) 2.2 (2.5) 1.3 (1.1) 0.7 (0.5) 2.7 (2.5) 0.0003 0.5-1.9/wk† 3.1 (3.2) 1.6 (1.8) 1.5 (1.6) 2.5 (2.4) 3.2 (3.2) 0.03 1–4/wk† 2.7 (2.9) 1.7 (1.9) 1.6 (1.6) 1.8 (1.5) 2.3 (2.5) 0.04 ≥5/wk 1.4 1.9 (2.1) 2.1 (2.2) (1.2) 2.4 (2.8) 0.

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